By Stefan Hohmann
Aquaporins summarizes the current wisdom during this increasing box of study, beginning with the structural research of water channel proteins. next chapters start with mammalian aquaporins, analyzing body structure and pathophysiology, research of knock-out version animals, and the rules of aquaporin functionality. additionally lined is the distribution and law of aquaporins in crops and the functionality of water and glycerol channels in microbial structures. Key good points* accomplished therapy of a topical examine box* Authored by means of international leaders within the box* Covers structural biology and body structure* Covers assorted experimental and organic platforms* Chapters on plant and microbial structures* huge therapy of mammalian body structure and pathophysiology* Structural research excellently illustrated
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Extra resources for Aquaporins
Smith, B. , Guggino, W. , and Agre, P. (1994a). Molecular structure of the water channel through aquaporin CHIP: The hourglass model. J. Biol. Chem. 269, 14648– 14654. Jung, J. , Bhat, R. , Preston, G. , Baraban, J. , and Agre, P. (1994b). Molecular characterization of an aquaporin cDNA from brain: Candidate osmoreceptor and regulator of water balance. Proc. Natl. Acad. Sci. USA 91, 13052–13056. Kachadorian, W. , Wade, J. , and DiScala, V. A. (2000). Vasopressin: Induced structural changes in toad bladder luminal membrane.
1994). Structural explanations for these functional differences are being sought. The primary amino acid sequences are highly homologous, yet a few sequence differences are present (Fig. 8B). Of note, AqpZ and orthodox aquaporins have a Ser following the second NPA motif in loop E (NPARS), whereas GlpF and aquaglyceroporins have an Asp at this site (NPARD) as well as a motif (GLYY) at the extracellular end of the third transmembrane domain. Electron microscopic studies of GlpF expressed in oocytes were interpreted as showing that the protein is a 1.
M¨uller, D. , and Engel, A. (2000). Surface topography of lens MIP (AQP0) supports two functions. J. Mol. Biol. 300, 779–789. , Wyatt, M. , Bhattacharya, S. , and Agre, P. (2000). Functional impairment of lens aquaporin in two families with dominantly inherited cataract. Human Mol. Genet. 9, 2329–2334. , Turck, C. , and Verkman, A. S. (1995). Immunolocalization of the mercurialinsensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc. Natl. Acad. Sci. USA 92, 4328–4331.
Aquaporins by Stefan Hohmann